what are t-cells and t-cytotoxic cells?
Answers
Helper T cells do not directly kill
infected cells, as cytotoxic T cells do.
Instead they help activate cytotoxic T
cells and macrophages to attack
infected cells, or they stimulate B cells
to secrete antibodies. Helper T cells
become activated by interacting with
antigen-presenting cells, such as
macrophages. Antigen-presenting cells
ingest a microbe, partially degrade it,
and export fragments of the microbe
i.e., antigens-to the cell surface, where
they are presented in association with
class II MHC molecules. A receptor on
the surface of the helper T cell then
binds to the MHC-antigen complex. But
this event alone does not activate the
helper T cell. Another signal is
required, and it is provided in one of
two ways: either through stimulation by
cytokine or through a costimulatory
reaction between the signaling protein,
B7, found on the surface of the
antigen-presenting cell, and the
receptor protein, CD28, on the surface
of the helper T cell. If the first signal
and one of the second signals arereceived, the helper T cell becomes
activated to proliferate and to stimulate
the appropriate immune cell. If only the
first signal is received, the T cell may
be rendered anergic—that is, unable to
respond to antigen.
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