What are the advantages and disadvantages of syrups?
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Advantages
i) It is easy to dispense unstable or degradable drugs in solution form.
ii) Suspension is the only choice if the drug is not soluble in water and non-aqueous solvent is not acceptable, e.g., corticosteroids suspension.
iii) Suspension is most suitable for drugs having unpleasant taste and odor e.g., Chloramphenical palmitate (bitter taste).
iv) The insoluble solids act as a reservoir and continuously supply the drug into solution, which is absorbed over a long period e.g., Protamine zinc-Insulin.
v) Drug in suspension exhibits a higher rate of bioavailability compared to the same drug of equivalent dose formulated in tablets or capsules. This is due to larger surface area and high dissolution, e.g., antacid suspension.
Disadvantages
1. Sedimentation of solids occasionally gives poor form of product. It may lead to caking (formation of compact mass), which is difficult to dispense.
2. Dose precision cannot be achieved unless suspensions are packed in unit dosage forms.
3. Sometimes microbial contamination takes place if preservation not added in accurate proportion.
4. A suspension being a bulky product, transportation cost is high.
i) It is easy to dispense unstable or degradable drugs in solution form.
ii) Suspension is the only choice if the drug is not soluble in water and non-aqueous solvent is not acceptable, e.g., corticosteroids suspension.
iii) Suspension is most suitable for drugs having unpleasant taste and odor e.g., Chloramphenical palmitate (bitter taste).
iv) The insoluble solids act as a reservoir and continuously supply the drug into solution, which is absorbed over a long period e.g., Protamine zinc-Insulin.
v) Drug in suspension exhibits a higher rate of bioavailability compared to the same drug of equivalent dose formulated in tablets or capsules. This is due to larger surface area and high dissolution, e.g., antacid suspension.
Disadvantages
1. Sedimentation of solids occasionally gives poor form of product. It may lead to caking (formation of compact mass), which is difficult to dispense.
2. Dose precision cannot be achieved unless suspensions are packed in unit dosage forms.
3. Sometimes microbial contamination takes place if preservation not added in accurate proportion.
4. A suspension being a bulky product, transportation cost is high.
Answered by
39
Syrups are semi-solid, concentrated solution of sucrose and other sugars, intended for oral use. They can be of medicated and non-mediated nature.
Advantages of syrup include:
- Resistance against microbial growth
- It helps in soothing the irritated tissues of throat
- Disguised the bad taste of medication
Disadvantages are:
- The sugar molecules inside the syrup can be crystallized
- It has a risk on dental carries
- Not suitable for diabetic patients
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