Question

What are the appropriate molecular cytogenetic approaches that should be used to diagnose the following cases? Why? Please explain.

1. Phenotypically abnormal child with balanced 46,XX,t(7;8)(q12;p22) karyotype.
2. A cancer case with a complex translocation that detected by karyotyping, but origins of involved chromosomes was not identified.
3. A balanced translocation carrier woman with recurrent abortions planning a new pregnancy.
4. Bronchial lavage material taken on suspicion of lung cancer
5. A case suspected of having terminal deletion in the short arm of chromosome 5.

Answer 1

Explanation:

3is the correct answer

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Answer 2

Answer:

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