what are the different and agent affecting this phenomenon?
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Review ArticleOpen Access
Polymorphism: The Phenomenon Affecting the Performance of Drugs
Kaisar Raza1*, Pramod Kumar1, Shanti Ratan1, Ruchi Malik1 and Shweta Arora2
1 Department of Pharmacy, School
Polymorphism is the ability of solid materials to exist in two or more crystalline forms with different arrangements or conformations of the constituents in the crystal lattice. These polymorphic forms of a drug differ in the physicochemical properties like dissolution and solubility, chemical and physical stability, flowability and hygroscopicity. These forms also differ in various important drug outcomes like drug efficacy, bioavailability, and even toxicity. Polymorphic studies are important as a particular polymorph can be responsible for a particular property which might not be exhibited by any other form. This review will discuss the applied nature of polymorphism starting from their preparation, characterization and pharmaceutical importance with a special emphasis on drugs.
Keywords: Crystal forms, Crystallization, Raman spectroscopy, XRD, Crystallography
IntroductionTop
The term polymorph has been derived from a Greek word “poly”, which means “many”, and “morph” “implying “form””. Hence, polymorphism refers to different structural forms of a chemical substance. It is defined as the ability of a solid material to exist in two or more
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