Question

what are the different mechanisms and factors that result in the severe hemolytic anemia in the beta thalassemia major patients

Answer 1

Answer:

Beta-thalassemias are caused by point mutations or, more rarely, deletions in the beta globin gene on chromosome 11, leading to reduced (beta+) or absent (beta0) synthesis of the beta chains of hemoglobin (Hb). Transmission is autosomal recessive; however, dominant mutations have also been reported.