Question

what are the different transformational stages of malarial parasite in human RBC?

Answer 1

plasmodium vivax is the malarial parasite which is responsible for malaria.infective stage of plasmodium from mosquito to man are called sporozoites and infective stage of plasmodium from human to mosquito are called gametocytes....
Basically plasmodium need two hosts to complete its life cycle - human and mosquito .


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Answer 2

Three opposing pathways are proposed for the release of malaria parasites  from infected erythrocytes  coordinated rupture of the two membranes surrounding mature parasites ; fusion of erythrocyte and parasitophorus vacuolar membranes (PVM) ; and liberation of parasites enclosed within the vacuole from the erythrocyte followed by PVM disintegration . Rupture by cell swelling should yield erythrocyte ghosts; membrane fusion is inhibited by inner-leaflet amphiphiles of positive intrinsic curvature , which contrariwise promote membrane rupture; and without protease inhibitors , parasites would leave erythrocytes packed within the vacuole.
 Therefore, we visualized erythrocytes releasing P. falciparum using fluorescent microscopy of differentially labeled membranes. Release did not yield erythrocyte ghosts, positive-curvature amphiphiles did not inhibit release but promoted it, and release of packed merozoites was shown to be an artifact.

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