Question

What are the disadvantages of optical imaging of cancer ?

Answer 1

Optical molecular imaging is a fast-developing field that holds great promise in cancer diagnosis. Over the past two decades, optical imaging has been actively investigated by researchers in both academic and industrial environments. Compared with other imaging modalities like MRI, CT, and ultrasound (US), optical imaging has many advantages. Technological improvements over the past few years have brought improved tissue penetration, sensitivity, and specificity of imaging cancer by optical methods. Novel devices like diffusion optical tomography (DOT) and the miniature endoscope have either been tested in clinical trials or approved by FDA for clinical use. Many of these new technologies can be integrated into or combined with MRI, CT, or US, providing a multimodality approach to further improve the accuracy of cancer diagnosis. Fast computational methods and ever-growing powerful computers make real-time optical imaging possible, bringing us closer to the possibility of on-site diagnosis.

Answer 2

Answer:

Perhaps a major limitation of the H&E slide in the era of “big-data” is the unassisted human interpretation currently used for analysis. To promote consistency and objective inter-observer agreement, most pathologists are trained to follow simple algorithmic decision trees that sufficiently stratify patients into reproducible groups b