What are the limitations of Friedel Crafts alkylation?
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The three key limitations of Friedel-Crafts alkylation are:
Carbocation Rearrangement - Only certain alkylbenzenes can be made due to the tendency of cations to rearrange.
Compound Limitations - Friedel-Crafts fails when used with compounds such as nitrobenzene and other strong deactivating systems.
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