Question

what are the OKAZAKI fragments​

Answer 1

Answer:

Okazaki fragments are short sequences of DNA nucleotides (approximately 150 to 200 base pairs long in eukaryotes) which are synthesized discontinuously and later linked together by the enzyme DNA ligase to create the lagging strand during DNA replication.

Okazaki fragments in bacteria and in bacteriophage T4 are 1000–2000 nucleotides long, but are only about 100–300 nucleotides in eukaryotes. Because DNA polymerases cannot initiate DNA synthesis, each Okazaki fragment is primed with a short RNA. The coordination of leading and lagging strand replication and the synthesis of RNA primers for lagging strand replication are explained elsewhere in this encyclopedia. For some organisms including Escherichia coli and bacteriophage T4, the same DNA polymerase is responsible for both leading and lagging strand DNA replication. For yeast and presumably all eukaryotes, there are different DNA polymerases for leading and lagging strand DNA replication. DNA polymerase epsilon (ε) is primarily responsible for leading strand replication and DNA polymerase delta (δ) is responsible for synthesis of Okazaki fragments and lagging strand replication.