Question

What are the significance of hoffmann bromide reaction?

Answer 1

This reaction involving degradation of amide and is popularly known as Hoffmann bromamide degradation reaction. The primary amine thus formed contains one carbon less than the number of carbon atoms in that amide. Hofmann elimination, also known as exhaustive methylation, is a process where a quaternary ammonium reacts to create a Tertiary amine and an alkene by treatment with excess methyl iodide followed by treatment with silver oxide, water, and heat.

Answer 2

Answer:

Hoffmann bromamide reaction mechanism generally includes the use of an alkali as a strong base to attack the amide, leading to the deprotonation and the subsequent generation of an anion. This reaction is used for the conversion of a primary amide to a primary amine with one less carbon atom.