Question

What are the two main targets currently used in anti hiv therapy?

Answer 1

Answer:

The two main targets currently used in anti-HIV therapy are reverse transcriptase and protease. However, integrase and the viral glycoproteins gp120 and gp41 are newer, alternative targets for anti-HIV therapy.

Answer 2

The two main targets currently used in anti-HIV therapy are reverse transcriptase (RT) and protease (PR).

• HIV stands for human immunodeficiency virus. It targets the immune system of a person by destroying cells that fight disease and infection. It is a sexually transmitted disease. In the current scenario, there is no effective cure for the disease. But with the help of proper medical attention, it can be controlled. If it is not treated, HIV can lead to AIDS (acquired immunodeficiency syndrome).
• There are strategies such as abstinence (not having sex), never sharing needles, and using condoms the right way every time you have sex to prevent getting the disease. You may also be able to take advantage of HIV prevention medicines such as pre-exposure prophylaxis (PrEP) and post-exposure prophylaxis (PEP).
• RT inhibitors fall into one of two classes, the RT inhibitors NRTIs (nucleoside-analog), which are incorporated into the growing DNA and serve as chain terminators and the RT inhibitors NNRTIs (non-nucleoside), which join RT and induce conformational changes that inhibit RT polymerisation activity.
• Protease inhibitors (PIs) competitively inhibit PR enzymatic function by binding to the active site of the enzyme. Inhibition of PR function prevents all proteolytic cleavage events associated with particle maturation, resulting in the formation of non-infectious, immature virus particles.
• The only way to know your HIV status is to get tested.

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