Question

What combination of genes of sickle cell anemia is lethal?

Answer 1

HbSHbS combination of genes of sickle cell anemia is lethal.

Explanation:  

• ‘Sickle Cell anaemia’ is a disease which is is autosomal recessive. As a result this is present only when both the genes which are inherited from different parents have the recessive form of the gene.  

• Hence the homogenous recessive gene of the patient it is lethal in nature. In such patient there is sickling of the most of the ‘red blood cells’.  

• As there is of sickling there is hemolysis of the cells and as a result this patient suffer from hypoxia since the red blood cell are incapable of carrying oxygen.

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Answer 2

The combination of genes of sickle cell anemia is lethal is as follows:

• Sickle cell anemia is caused by the altered form of hemoglobin. As a co-dominant trait, it is inherited.
• Both the normal and sickle red blood cells are expressed by heterozygous individuals specifically.
• Sickle cell anemia is caused by the mutations occurs in HBB gene.
• This can cause life threatening complication which can be difficulty in breathing, chest pain, acute chest syndrome.