what do you mean by presynaptic knob
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Presynaptic Knob
An area at the end of an axon that contains neurotransmitters in synaptic vesicles.
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The prefixes "pre-" and "post-" reflect the direction of synaptic transmission: presynaptic is the transmitting side (synaptic knob) and postsynaptic is the receiving side (dendrite, soma, or effector). Synaptic knobs contain many membrane-bounded synaptic vesicles , 40 to 100 nanometers in diameter.
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