Question

What do you understand by exhausted cell?

Answer 1

Abstract. T cell exhaustion is a state of T cell dysfunction that arises during many chronic infections and cancer. It is defined by poor effector function, sustained expression of inhibitory receptors and a transcriptional state distinct from that of functional effector or memory T cells...

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Answer 2

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As exhausted T cells emerge sequential phenotypic and functional changes occur. Exhausted T cells express arrays of inhibitory molecules and distinctive patterns of cytokine receptors, transcription factors and effector molecules, which distinguish these cells from conventional effector, memory and anergic T cells.

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Answer 3

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As exhausted T cells emerge sequential phenotypic and functional changes occur. Exhausted T cells express arrays of inhibitory molecules and distinctive patterns of cytokine receptors, transcription factors and effector molecules, which distinguish these cells from conventional effector, memory and anergic T cells.

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