What does low serum corticosterone, but high plasma ACTH indicate in stressed rats?
Answers
Answer:
Explanation:
After almost a month of Chronic Unpredictable Mild Stress (CUMS), both of my control rats (no stress) and stress-model rats exhibit low serum corticosterone concentration. Surprisingly, the level of ACTH in stress-model rats were significantly higher compared to control rats. Is it a common observation? Because most CUMS literature i found report high corticosterone level in their stressed rats.
Answer:
Explanation:
If you want to explore further what's going on in your rats I suggest looking at the dexamathasone suppression test to measure HPA negative feedback (see attached paper).
After almost a month of Chronic Unpredictable Mild Stress (CUMS), both of my control rats (no stress) and stress-model rats exhibit low serum corticosterone concentration. Surprisingly, the level of ACTH in stress-model rats were significantly higher compared to control rats. Is it a common observation