What happens due to deficiency of leptin and serotonin hormones?
Answers
Answer:
Leptin receptor deficiency is a condition that causes severe obesity beginning in the first few months of life. Affected individuals are of normal weight at birth, but they are constantly hungry and quickly gain weight. The extreme hunger leads to chronic excessive eating (hyperphagia) and obesity.
People who feel unusually irritable or down for no apparent reason may have low serotonin levels. Depression: Feelings of sadness, hopelessness, and anger, as well as chronic fatigue and thoughts of suicide, may indicate depression. Anxiety: Low serotonin levels may cause anxiety.
Answer:
Leptin, an adipocyte-derived hormone, can directly inhibit serotonin production and release by the raphe nuclei neurons of the brainstem. The action of leptin is mediated by LepR, also known as the leptin/obese receptor ObRb, expressed on these neurons.