Question

What happens to the functionality of a protein if the pH changes

Answer 1

Hey mate here's your answer

The interactions between the side chains of the amino acids determine the shape of a protein.



Tertiary Structure

Four types of attractive interactions determine the shape and stability of a protein. The two that pH changes affect are salt bridges (a) and hydrogen bonding(b).

Salt Bridges

Salt bridges are ionic bonds between positively and negatively charged side chains of amino acids. An example is the attraction between a

-COO-

ion of lysine and an

-NH

+3

ion of aspartic acid.

Increasing the pH by adding a base converts the

-NH

+3

ion to a neutral

-NH2

group.

Decreasing the pH by adding an acid converts the

–COO-

ion to a neutral

-COOH

group.

In each case the ionic attraction disappears, and the protein shape unfolds.

Hydrogen Bonding

Various amino acid side chains can hydrogen bond to each other.

Changing the pH disrupts the hydrogen bonds, and this changes the shape of the protein.

Hope it helps you

Answer 2

HEYA!!!


HERE IS YOUR ANSWER,


> Changes in pH change the attractions between the groups in the side chains of the protein.

Explanation:

> The interactions between the side chains of the amino acids determine the shape of a protein.

> The pH of a solution can have several effects of the structure and activity of enzymes.

> For example, pH can have an effect of the state of ionization of acidic or basic amino acids.

> Acidic amino acids have carboxyl functional groups in their side chains.

> Basic amino acids have amine functional groups in their side chains.

> If the state of ionization of amino acids in a protein is altered then the ionic bonds that help to determine the 3-D shape of the protein can be altered.

> This can lead to altered protein recognition or an enzyme might become inactive.


HOPE IT HELPS YOU,
THANK YOU.☺️