Question

What happens to the glucose present in the filtrate when it reaches the proximal convoluted tubule?​

Answer 1

Explanation:

The proximal convoluted tubule avidly reabsorbs filtered glucose into the peritubular capillaries so that it is all reabsorbed by the end of the proximal tubule. ... If the filtered load of glucose overwhelms the proximal tubule transport mechanisms, glucose escapes to the loop of Henle

Answer 2

Answer:

Increased Solute Loads in the Distal Nephron Produce an Osmotic Diuresis

The proximal convoluted tubule avidly reabsorbs filtered glucose into the peritubular capillaries so that it is all reabsorbed by the end of the proximal tubule. The mechanism for glucose reabsorption was described in Chapter 7.4. The proximal tubule is the only site for glucose reabsorption. If the filtered load of glucose overwhelms the proximal tubule transport mechanisms, glucose escapes to the loop of Henle. There is no reabsorption of glucose beyond the proximal tubule, and the glucose becomes progressively more concentrated as the nephron reabsorbs water and salt. The glucose exerts an osmotic pressure and produces an osmotic diuresis, the severity being directly proportional to the amount of excreted glucose. This is the origin of the polyuria of persons with uncontrolled diabetes mellitus in which the plasma concentration of glucose exceeds its renal threshold. Any osmotically active material in the distal nephron will have this effect. Mannitol is freely filtered by the kidney but neither secreted nor reabsorbed. Injection of mannitol will produce an osmotic diuresis that is directly proportional to the amount of mannitol injected.

Explanation:

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