What happens when aqueous solution of glucose is kept for sometime? name the phenomena and discuss the mechanism involved
Answers
The term “mutarotation” originates from the observed change in the optical rotation of the α- and β- anomers of glucose upon dissolution in water. Due to ring-chain tautomerism, the α- and β- forms slowly interconvert until equilibrium is established.
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Nothing will happen if the environment is kept aseptic. Only D-Glucose will be used in the solution.
Because the beta form of glucose is more stable than the alpha, if you put alpha D-Glucose in for a longer length of time, a certain quantity of alpha D-Glucose will be changed to Beta D-Glucose. Mutarotation is the name for this phenomenon.
The hydroxyl group in beta glucose is on the equatorial position, and according to the chair form conformation rule, if the bulkier group is present on the equatorial position, the stability is increased.
If a pure crystalline sample of glucose (such as -D-glucopyranose) is dissolved in water, the structure opens to form the carbonyl group and then closes; this process repeats itself; over time, some -D-glucopyranose undergoes mutarotation to become -D-glucopyranose, and the rotation of the solution changes from +18.7 to an equilibrium value of +52.5.