Question

What happens when double-stranded breaks (dsb) occur in cells in g1 or g0 phases of the cell cycle?

Answer 1

Explanation:

The NHEJ pathway occurs mainly in the G0 and G1 phase of the cell cycle by joining DSB ends directly or after limited processing, whereas HR uses a sister homolog as a template for repair during late S and G2 phases [5]. Encompassing these repair pathways, mammalian cells also possess a DNA damage response (DDR).

Answer 2

Explanation:

The NHEJ pathway occurs mainly in the G0 and G1 phase of the cell cycle by joining DSB ends directly or after limited processing, whereas HR uses a sister homolog as a template for repair during late S and G2 phases [5]. Encompassing these repair pathways, mammalian cells also possess a DNA damage response (DDR).