Question

What i incrase of formaldehde> acetaldehyde>propionaldehyde?

Answer 1

Acetaldehyde, propionaldehyde, formaldehyde and acrolein have previously been reported to possess indirect sympathomimetic activity. The objective of this study was to examine the action of these aldehydes on isolated smooth muscle systems. Acetaldehyde and propionaldehyde were relatively equipotent and reversible in producing contractile responses in rat vas deferens which were blocked by reserpine pretreatment. These aldehydes produced an increase in loss of radioactivity after exposure of tissues to 14C norepinephrine and decreased accumulation of 14C norepinephrine and 45Ca in isolated smooth muscle systems. Formaldehyde and acrolein produced irreversible contractile responses in rat vas deferens which were not blocked by reserpine pretreatment. Loss of radioactivity after exposure of tissues to norepinephrine nonrepinephrine was increased in a nonlinear fashion and both aldehydes also reduced accumulation of 14C norepinephrine and 45Ca. It appears that all 4 aldehydes interact with tissue norepinephrine stores and affect nonspecific membrane calcium binding sites. Formaldehyde and acrolein are potentially more toxic than acetaldehyde and propionaldehyde in similar concentrations and may cause irreversible contraction of smooth muscle by altering membrane continuity.

Answer 2

Answer:

The oxygen atom of the carbonyl group engages in hydrogen bonding with a water molecule. The solubility of aldehydes is therefore about the same as that of alcohols and ethers. Formaldehyde, acetaldehyde, and acetone are soluble in water. As the carbon chain increases in length, solubility in water decreases