What is a Macrophages define briefly
Answers
Answer:
Macrophages (abbreviated as Mφ, MΦ or MP) (Greek: large eaters, from Greek μακρός (makrós) = large, φαγεῖν (phagein) = to eat) are a type of white blood cell of the immune system that engulfs and digests cellular debris, foreign substances, microbes, cancer cells, and anything else that does not have the type of proteins specific to healthy body cells on its surface[2] in a process called phagocytosis.
Answer:
Macrophages are ubiquitous in the body and play a prominent role in the immune response. Functionally, mucosal macrophages have important effects on bacterial clearance, maintaining homeostasis, and protective immunity. The small intestine is replete with resident macrophages that can be found in the lamina propria and within Peyer patches. Small-intestine macrophages are derived from the common bone marrow myeloid precursor that produces monocytes, macrophages, and dendritic cells (DCs). The small-intestine macrophages differ from circulating macrophages by expressing surface markers unique to their role in mucosal defense . It is known that mediators in the mucosal environment are capable of modifying and conditioning DCs in the intestine as well as giving regulatory T cells gut-homing properties, and it is suspected that the same is true in the development of mucosal macrophages.