What is a point mutation? Give an example
Answers
Explanation:
A point mutation or substitution is a genetic mutation where a single nucleotide base is changed, inserted or deleted from a sequence of DNA or RNA. Point mutations have a variety of effects on the downstream protein product—consequences that are moderately predictable based upon the specifics of the mutation.
Answer:
Mutation in single nucleotide base of a DNA segment is called as a point mutation. It can introduce a premature stop codon, or a nonsense codon, by addition or deletion of the base, in the transcribed mRNA (nonsense mutation) or changes a codon specifying a different amino acid by substitution of one base (missense mutation). For example, replacement of A by T at the 17th nucleotide of the Hbb gene changes the codon GAG (glutamic acid) to GTG (which encodes valine) and causes sickle cell anemia.