Question

what is allosteric modulation?

Answer 1

Answer:

an allosteric modulator is a substance which indirectly influences the effect of primary ligand that directly activities and de activities the function of the target protein. targets may be metabotropic, ionotropic and nuclear receptors, enzymes and transporters.

Answer 2

An allosteric inhibitor by binding to allosteric site alters the protein conformation in active site of enzyme which consequently changes the shape of active site. Thus enzyme no longer remains able to bind to its specific substrate. Hence enzyme is unable to perform it's catalytic activity i.e enzyme is now inactive....༄