What is carbooxyhaemoglobin ?
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carboxyhaemoglobin is a stable complex of carbon monoxide and hemoglobin that forms in red blood cells upon contact with carbon monoxide. Carboxyhemoglobin is often mistaken for the compound formed by the combination of carbon dioxide and hemoglobin, which is actually carbaminohemoglobin.
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CARBOOXYHAEMOGLOBIN :
COhb »»
- In general, a carboxyhemoglobin (COHb) level of 10-20% will only cause slight headaches [NIOSH 1972] and a COHb of 11-13% will have no effect on hand and foot reaction time, hand steadiness, or coordination [Stewart and Peterson 1970].
- At a COHb of 35%, manual dexterity is impaired [Stewart 1975].
- Unequivocal increase in COHb indicates either a hemolytic process or more commonly carbon-monoxide poisoning.
- Increased COHb reduces tissue oxygenation but this is not the only mechanism of CO toxicity.
- Laboratory measurement of COHb is the only routinely available blood test for diagnosis of CO poisoning.
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