what is cell contancy and what is it apparent relation to regenarate capacity
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The regenerative capacity of stem cells leads to their potential in improving patient outcomes in respiratory disease. It is possible to imagine therapies that either stimulate regeneration from endogenous stem cells or that involve the transplantation of exogenous stem cells. “Mesenchymal stromal cells” (MSCs) have been trialed in a number of respiratory diseases including COPD and IPF due to their paracrine anti-inflammatory and anti-fibrotic actions (Shi et al., 2010; Geiger et al., 2017). However, these cells are not capable of transdifferentiation to lung lineages (Kotton et al., 2005), likely do not engraft long-term and, despite their favorable safety profile, no clinical trials have yet suggested efficacy in human patients (Weiss, 2018).
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