what is chain termination method? Why chain was terminated at a certain point? Also find differences between dNTP and ddNTP?
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Sanger DNA sequencing is also known as the chain-termination method of sequencing. ... ddNTPs result in termination of the DNA strand because ddNTPs lack the 3'-OH group required for phosphodiester bond formation between nucleotides. Without this bond, the chain of nucleotides being formed is terminated.
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