what is chromosome doubling and colchicine treatment ?
Answers
A doubled haploid (DH) is a genotype formed when haploid cells undergo chromosome doubling. Artificial production of doubled haploids is important in plant breeding.
Haploid cells are produced from pollen or egg cells or from other cells of the gametophyte, then by induced or spontaneous chromosome doubling, a doubled haploid cell is produced, which can be grown into a doubled haploid plant. If the original plant was diploid, the haploid cells are monoploid, and the term doubled monoploid may be used for the doubled haploids. Haploid organisms derived from tetraploids or hexaploids are sometimes called dihaploids (and the doubled dihaploids are, respectively, tetraploid or hexaploid).
Conventional inbreeding procedures take six generations to achieve approximately complete homozygosity, whereas doubled haploidy achieves it in one generation.[1] Dihaploid plants derived from tetraploid crop plants may be important for breeding programs that involve diploid wild relatives of the crops.
Colchicine is a medication used to treat gout and Behçet's disease. In gout it is less preferred to NSAIDs or steroids. Other uses include the prevention of pericarditis and familial Mediterranean fever. It is taken by mouth. Common side effects include gastrointestinal upset, particularly at high doses.
Formula: C22H25NO6
CAS ID: 64-86-8
Molar mass: 399.437 g/mol
Elimination half-life: 26.6-31.2 hours
Metabolism: Metabolism, partly by CYP3A4
Trade name: Colcrys, Mitigare, others
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