What is Cushing’s syndrome and Addison’s disease?
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1. What is the difference between Cushing disease and Cushing syndrome?
Cushing disease is caused by a pituitary gland tumor (usually benign) that over-secretes the hormone ACTH, thus overstimulating the adrenal glands' cortisol production. Cushing syndrome refers to the signs and symptoms associated with excess cortisol in the body, regardless of the cause. In addition to a pituitary tumor, taking steroid hormones (often used to treat cancer or autoimmune diseases), adrenal gland tumors, and ACTH-producing tumors outside the pituitary gland can cause Cushing syndrome.
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2. What is Addison disease?
Addison disease is the lack of cortisol due to adrenal dysfunction, also called adrenocortical insufficiency. Damage or destruction of the adrenal cortex, leading to a lack of cortisol and other adrenal steroids, especially aldosterone, causes Addison disease.
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3. My doctor told me that my extra ACTH is not produced in my pituitary gland. What is going on?
In addition to an excess of ACTH from the pituitary gland, it can also come from elsewhere in the body. This is known as ectopic production of ACTH, which comes from tumors elsewhere in the body, usually (but not always) in the lungs. This causes Cushing syndrome and may alert your doctor to the presence of a tumor.
Cushing disease is caused by a pituitary gland tumor (usually benign) that over-secretes the hormone ACTH, thus overstimulating the adrenal glands' cortisol production. Cushing syndrome refers to the signs and symptoms associated with excess cortisol in the body, regardless of the cause. In addition to a pituitary tumor, taking steroid hormones (often used to treat cancer or autoimmune diseases), adrenal gland tumors, and ACTH-producing tumors outside the pituitary gland can cause Cushing syndrome.
^ Back to top
2. What is Addison disease?
Addison disease is the lack of cortisol due to adrenal dysfunction, also called adrenocortical insufficiency. Damage or destruction of the adrenal cortex, leading to a lack of cortisol and other adrenal steroids, especially aldosterone, causes Addison disease.
^ Back to top
3. My doctor told me that my extra ACTH is not produced in my pituitary gland. What is going on?
In addition to an excess of ACTH from the pituitary gland, it can also come from elsewhere in the body. This is known as ectopic production of ACTH, which comes from tumors elsewhere in the body, usually (but not always) in the lungs. This causes Cushing syndrome and may alert your doctor to the presence of a tumor.
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Cushing’s syndrome:
a tumor of the adernal cortex may secret too much cortisol to produce Cushing's syndrome.
Symptoms:
high blood sugar, appearance of sugar in the urine,obesity,
wasting of limb muscle, rise in blood volume,
high blood pressure.
In males excessive hair growth.
In females, masculinization with beard, moustache etc.
Addison's Disease:
a destruction of adrenal cortex by diseases like tuberculosis produces addison's disease due to the deficiency of both glucocorticoids and mineralocorticoid.
Symptoms include:
a bronze like pigmentation of skin,
low blood sugar,
nausea,
vomiting,
diarrhoea.
thanks...
nice to help you
a tumor of the adernal cortex may secret too much cortisol to produce Cushing's syndrome.
Symptoms:
high blood sugar, appearance of sugar in the urine,obesity,
wasting of limb muscle, rise in blood volume,
high blood pressure.
In males excessive hair growth.
In females, masculinization with beard, moustache etc.
Addison's Disease:
a destruction of adrenal cortex by diseases like tuberculosis produces addison's disease due to the deficiency of both glucocorticoids and mineralocorticoid.
Symptoms include:
a bronze like pigmentation of skin,
low blood sugar,
nausea,
vomiting,
diarrhoea.
thanks...
nice to help you
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