what is diapedesis...marks-3...needed details answer,,best answer will be mark as brainleast
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Answers
the passage of blood cells through the intact walls of the capillaries, typically accompanying inflammation.
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Diapedesis :--
The movement or passage of blood cells, especially white blood cells, through intact capillary walls into surrounding body tissue.
It's importance and mechanism:--
Diapedesis is the process by which T lymphocytes migrate across venular blood vessel walls to enter various tissues and organs. The capacity to transmigrate is of critical importance for the T lymphocyte at all life stages, from entry of T-cell precursors into the thymus for T-cell development to entry of T cells into lymph nodes for activation, or migration of effector T cells into tissues to fight infections. Diapedesis occurs via a multi-step pathway including lymphocyte rolling, signalling, firm adhesion and transmigration.
There are mainly four steps of this biological phenomenon :--
1. Leukocyte rolling:--
Leukocytes rolling is a phenomenon by which leukocytes in circulation in the blood stream gets in close contact with the blood vessel walls.
2. Signalling :--
The interaction between a chemokine and its chemokine receptor leads to an intracellular signalling event, which in turn activates adhesion molecules of the integrin family.
3. Firm adhesion:--
Following activation integrins display high affinity binding sites which interact with cell adhesion molecules (CAMs) on the vascular wall, resulting in lymphocyte halt and firm adhesion.
4. Transmigration:--
The process of transmigration is less well characterised compared to the other steps, especially with a focus on T lymphocytes.
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