Question

What is difference between scrub typhus test and weil flix?

Answer 1

WEIL FELIX:-
Weil-Felix is a nonspecific agglutination test which detects anti-rickettsial antibodies in patient’s serum. Weil-Felix test is based on cross-reactions which occur between antibodies produced in acute rickettsial infections with antigens of OX (OX 19, OX 2, and OXK) strains of Proteus species. Dilution of patient’s serum are tested against suspensions of the different Proteus strains.

SRUB TYPHUS:-
Scrub typhus often presents as fever with little to distinguish it clinically from co-endemic diseases such as typhoid, leptospirosis, and dengue. The presence of an eschar supports the diagnosis but is variably present.2 Diagnosis, therefore, depends on clinical suspicion, prompting the clinician to request an appropriate laboratory investigation, and failure to diagnose the disease will likely result in treatment with ineffective β-lactam–based regimens.

The mainstay in scrub-typhus diagnostics remains serology. The oldest test in current use is the Weil–Felix OX-K agglutination reaction, which is inexpensive, easy to perform, and results are available overnight; however, it lacks specificity and sensitivity3. The indirect fluorescent antibody (IFA) test is more sensitive, and results are available in a couple of hours; however, the test is more expensive and requires considerable training . IFA uses fluorescent anti-human antibody to detect specific antibody from patient serum bound to a smear of scrub-typhus antigen and is currently the reference standard.
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