Question

What is fischer indole synthesis.

Answer 1

The Fischer indole synthesis is a chemical reaction that produces the aromatic heterocycle indole from a phenylhydrazine and an aldehyde or ketone under acidic conditions. The reaction was discovered in 1883 by Emil Fischer. Today antimigraine drugs of the triptan class are often synthesized by this method.

Answer 2

In Fischer Indole Reaction, we use substituted phenyl-hydrazine and either an aldehyde or a ketone under acidic conditions to produce Hetrocyclic Aromatic Indole.

--> This reaction was found by Email Fischer in 1883.

--> This reaction has pharmaceutical importance as this is used to prepare Triptan class drugs used for migraine treatment.

--> This type of reaction is also known as ring forming reaction.

--> Acid catalysts such as HCl, H2SO4 and polyphosphoric acid are more commonly used and yield successful results.