Question

what is Gabriel Pthalimide reaction used in the synthesis of?

Answer 1

otassium phthalimide is a -NH2-synthon which allows the preparation of primary amines by reaction with alkyl halides. After alkylation, the phthalimid is not nucleophile and does not react anymore. Product is cleaved by reaction with base or hydrazine, which leads to a stable cyclic product.Mechanism of the Gabriel SynthesisNote: Phthalimide is acidic!

Answer 2

Answer :-

The Gabriel synthesis is a chemical reaction that transforms primary alkyl halides into primary amines. Traditionally, the reaction uses potassium phthalimide. The name of the reaction comes from the German chemist Siegmund Gabriel.

Reaction in attachment.

Remarks :-

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