Question

what is gastrorententive drug dilvery system

Answer 1

A controlled drug delivery system with prolonged residence time in the stomach is of particular interest for drugs that i) are locally active in the stomach, ii) have an absorption window in the stomach or in the upper small intestine, iii) are unstable in the intestinal or colonic environment, or iv) exhibit low solubility at high pH values. This article gives an overview of the parameters affecting gastric emptying in humans as well as on the main concepts used to design pharmaceutical dosage forms with prolonged gastric residence times. In particular, bioadhesive, size-increasing and floating drug delivery systems are presented and their major advantages and shortcomings are discussed. Both single- and multiple-unit dosage forms are reviewed and, if available, results from in vivo trials are reported.

Answer 2

INTRODUCTION:Owing to tremendous curative benefits of the oral controlled release dosage forms are being preferred as the interesting topic of research over the past 3 decades 1. The much obvious interest in this scenario is owing to its two fold advantage. Primarily, the oral controlled release dosage forms have the potential to upkeep an effective concentration in system for a longer duration

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