what is gene set meaning?
Answers
A gene set is a collection of genes associated with a specific biological process (e.g. cell cycle), location (e.g. on chromosome 1), disease (e.g. breast cancer), or even the set of genes that are present in a given pathway (e.g. the set of 128 genes involved in the KEGG cell cycle pathway).
Gene set enrichment analysis (GSEA) (also functional enrichment analysis) is a method to identify classes of genes or proteins that are over-represented in a large set of genes or proteins, and may have an association with disease phenotypes.
In the context of absolute gene expression, genes are ranked by mean tissue, cell type, or cell line signal. In relative gene expression biosets, the mean signal of a gene is compared to a “reference,” defined as the median signal among all tissues, cell types, or cell lines.