What is Glycolysis? Write it steps.
Answers
Glycolysis is the sequence of 10 enzyme catalyzed reactions that converts glucose into pyruvate with the simultaneous production of ATP. The overall reaction of glycolysis which occurs in the cytoplasm is represented simply as: C6H12O6 + 2 NAD+ + 2 ADP + 2 P —> 2 pyruvic acid, (CH3(C=O)COOH + 2 ATP + 2 NADH + 2 H+
Glycolysis Explained in 10 Easy Steps
Step 1: Hexokinase. ...
Step 2: Phosphoglucose Isomerase. ...
Step 3: Phosphofructokinase. ...
Step 4: Aldolase. ...
Step 5: Triosephosphate isomerase. ...
Step 6: Glyceraldehyde-3-phosphate Dehydrogenase. ...
Step 7: Phosphoglycerate Kinase. ...
Step 8: Phosphoglycerate Mutase....
Glycolysis is the central pathway for the glucose catabolism in which glucose (6-carbon compound) is converted into pyruvate (3-carbon compound) through a sequence of 10 steps.
Glycolysis takes place in both aerobic and anaerobic organisms and is the first step towards the metabolism of glucose.
The glycolytic sequence of reactions differs from one species to the other in the mechanism of its regulation and the subsequent metabolic fate of the pyruvate formed at the end of the process.
During glycolysis, a single mole of 6-carbon glucose is broken down into two moles of 3-carbon pyruvate by a sequence of 10 enzyme-catalyzed sequential reactions. These reactions are grouped under 2 phases, phase I and II.
Stage I comprises “preparatory” reactions which are not redox reactions and do not release energy but instead lead to the production of a critical intermediate of the pathway.
Stage I consists of the first five steps of the glycolysis process.
Similarly, in Stage II, redox reactions occur, energy is conserved in the form of ATP, and two molecules of pyruvate are formed.
The last five reactions of glycolysis constitute phase II.
steps-
Phosphorylation of glucose
Isomerization of Glucose-6-phosphate
Phosphorylation of fructose-6-phosphate
Cleavage of fructose 1, 6-diphosphate
Isomerization of dihydroxyacetone phosphate