What is hepatic clearance and hepatic extraction ration in pharmacokinetics?
Answers
Hepatic drug clearance can be defined as the volume of blood perfusing the liver that is cleared of the drug per unit of time....
The ratio of the hepatic clearance of a drug to the hepatic blood flow is called the extraction ratio of the drug. Extraction ratio can be generally classified as high (>0.7), intermediate (0.3-0.7) or low (<0.3) according to the fraction of drug removed during one pass through the liver.
Answer:
Hepatic drug clearance can be defined as the volume of blood perfusing the liver that is cleared of the drug per unit of time....
The ratio of the hepatic clearance of a drug to the hepatic blood flow is called the extraction ratio of the drug. Extraction ratio can be generally classified as high (>0.7), intermediate (0.3-0.7) or low (<0.3) according to the fraction of drug removed during one pass through the liver.
Explanation: