what is lymph and what is neurone?
Answers
Answer:
The lymphatic (lim-FAT-ik) system works to keep body fluid levels in balance and to defend the body against infections. It is made up of a network of lymphatic vessels that carry lymph — a clear, watery fluid that contains proteins, salts, and other substances — throughout the body.
Explanation:
The lymphatic (lim-FAT-ik) system works to keep body fluid levels in balance and to defend the body against infections. It is made up of a network of lymphatic vessels that carry lymph — a clear, watery fluid that contains proteins, salts, and other substances — throughout the body.
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Explanation:
Barrier tissue immune responses are regulated in part by nociceptors. Nociceptor ablation alters local immune responses at peripheral sites and within draining lymph nodes (LNs). The mechanisms and significance of nociceptor-dependent modulation of LN function are unknown. Using high-resolution imaging, viral tracing, single-cell transcriptomics, and optogenetics, we identified and functionally tested a sensory neuro-immune circuit that is responsive to lymph-borne inflammatory signals. Transcriptomics profiling revealed that multiple sensory neuron subsets, predominantly peptidergic nociceptors, innervate LNs, distinct from those innervating surrounding skin. To uncover LN-resident cells that may interact with LN-innervating sensory neurons, we generated a LN single-cell transcriptomics atlas and nominated nociceptor target populations and interaction modalities.
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