Question

What is mean bohr effect

Answer 1

The Bohr effect is a physiological phenomenon first described in 1904 by the Danish physiologist Christian Bohr: hemoglobin's oxygen binding affinity (see oxygen–haemoglobin dissociation curve) is inversely related both to acidity and to the concentration of carbon dioxide.[1] That is, the Bohr effect refers to the shift in the oxygen dissociation curve caused by changes in the concentration of carbon dioxide or the pH of the environment. Since carbon dioxide reacts with water to form carbonic acid, an increase in CO2results in a decrease in blood pH, resulting in hemoglobin proteins releasing their load of oxygen. Conversely, a decrease in carbon dioxide provokes an increase in pH, which results in hemoglobin picking up more oxygen.

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Answer 2

Bohr’s effect:

A sigmoid curve is obtained when percentage saturation of Hb with O2 is plotted against pO2. This curve is called Oxygen Dissociation Curve.

Factors affecting dissociation curve are pCO2, H+ concentration and temperature.

In tissues, low pO2, high pCO2, high H+ concentration and higher temperature are favorable for dissociation of O2 from oxyhemoglobin.

Shift of dissociation curve to right due to increase in pCO2 is called Bohr’s effect.

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