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Edward Jenner is considered the founder of vaccinology in the West in 1796, after he inoculated a 13 year-old-boy with vaccinia virus (cowpox), and demonstrated immunity to smallpox. In 1798, the first smallpox vaccine was developed.
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Tripartite Pact, agreement concluded by Germany, Italy, and Japan on September 27, 1940, one year after the start of World War II. It created a defense alliance between the countries and was largely intended to deter the United States from entering the conflict.
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