What is" Mechanism of Blood Clotting"?
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Answer:
The mechanism of coagulation involves activation, adhesion, and aggregation of platelets along with deposition and maturation of fibrin. Disorders of coagulation can result in bleeding (hemorrhage or bruising) or obstructive clotting (thrombosis).
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HOME / ... / HOW BLOOD CLOTS
How Blood Clots
By Joel L. Moake, MD, Baylor College of Medicine
Last full review/revision Apr 2020| Content last modified Apr 2020
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Hemostasis is the body's way of stopping injured blood vessels from bleeding. Hemostasis includes clotting of the blood.
Too little clotting can cause excessive bleeding from minor injury
Too much clotting can block blood vessels that are not bleeding
Consequently, the body has control mechanisms to limit clotting and dissolve clots that are no longer needed. An abnormality in any part of the system that controls bleeding can lead to excessive bleeding or excessive clotting, both of which can be dangerous. When clotting is poor, even a slight injury to a blood vessel may lead to severe blood loss. When clotting is excessive, small blood vessels in critical places can become clogged with clots. Clogged vessels in the brain can cause strokes, and clogged vessels leading to the heart can cause heart attacks. Pieces of clots from veins in the legs, pelvis, or abdomen can travel through the bloodstream to the lungs and block major arteries there (pulmonary embolism).
Hemostasis involves three major processes:
Narrowing (constriction) of blood vessels
Activity of cell-like blood particles that help in blood clotting (platelets)
Activity of proteins found in blood that work with platelets to help the blood clot (clotting factors)