what is non consecutive genes
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A history of two or three consecutive miscarriages did not alter ... for Clinical Genetics in the Netherlands between January ..
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Good clinical practice starts with a clear definition of the clinical problem. Currently, no consensus exists on the definition of recurrent miscarriage (Stirrat, 1990; Farquharson et al., 2005). Several national and international guidelines have been published on this topic, but their definitions vary with regard to the number of preceding miscarriages as well as the sequence of previous pregnancies (ACOG, 2002; RCOG, 2003; Jauniaux et al. (ESHRE), 2006). To date, the American College of Obstetrics and Gynaecology (ACOG) defines recurrent miscarriage as two or more consecutive miscarriages and the European Society of Human Reproduction and Embryology (ESHRE) defines recurrent miscarriage as three or more consecutive miscarriages (ACOG, 2002; ESHRE, 2006). In contrast to these guidelines, the definitions from the Royal College of Obstetricians and Gynaecologists (RCOG), ‘three or more miscarriages’, and the Dutch Society of Obstetrics and Gynaecology (NVOG), ‘two or more miscarriages’, do not contain the word consecutive (RCOG, 2003; NVOG, 2007). As a result of this discrepancy, it is unclear in daily clinical practice which couples should be diagnosed with recurrent miscarriage and when to start the diagnostic work-up.
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