Question

What is obesity and it's pathology ?

Answer 1

Abnormal increase in proportion of fat cells in viscera and subcutaneous tissues of body due to excessive intake as compared to output of calories.
Term Obesity is derived from Latin word 'obesus' meaning 'having eaten'. Root cause of Obesity is overeating as suggested by its very name.

Pathology -
Obesity in majority of cause is regulatory.
Involves some mechanisms regulating food intake, which may be
1. Neurological.
2. Metabolic.
3. Psychological.

Answer 2

Obesity is an exaggeration of normal adiposity and is a central player in the pathophysiology of diabetes mellitus, insulin resistance, dyslipidemia, hypertension, and atherosclerosis, largely due to its secretion of excessive adipokines. Obesity is a major contributor to the metabolic dysfunction involving lipid and glucose, but on a broader scale, it influences organ dysfunction involving cardiac, liver, intestinal, pulmonary, endocrine, and reproductive functions. Inflammatory, insulin-resistant, hypertensive, and thrombotic-promoting adipokines, which are atherogenic, are counterbalanced by anti-inflammatory and anti-atherogenic adipocyte hormones such as adiponectin, visfatin, and acylation-stimulating protein, whereas certain actions of leptin and resistin are pro-atherogenic.