what is pyruvate decarboxylation
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Pyruvate decarboxylation or pyruvate oxidation, also known as the link reaction, is the conversion of pyruvate into acetyl-CoA by the enzyme complex pyruvate dehydrogenase complex. The reaction may be simplified as: 1 Pyruvate + 1 NAD+ + CoA → 1 Acetyl-CoA + NADH + CO2 + H+
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Pyruvate decarboxylation is an oxidative decarboxylation reaction, or an oxidation reaction where a carboxylate group is removed. This reaction converts pyruvate which was produced through glycolysis to acetyl CoA to be used in the Citric Acid Cycle.
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