Question

What is right about the Hantzsch synthesis?


It is the condensation of 1,4-diketone with ammonia or primary amine.


It involves the condensation of α-haloketone with β-ketoester in the presence of nitrogen-containing base.


It is the cyclization of 1,4-diketone under acidic conditions


1,4-diketone is heated with phosphorous pentasulphide.


Question 6​

Answer 1

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The Hantzsch synthesis is a four-component reaction between an aldehyde, two equivalents of a β-ketoester and ammonia, followed by oxidation to give a pyridine-3,5-dicarboxylate. Subsequent decarboxylation gives the corresponding pyridines. H. G. O.

Answer 2

Answer:

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