What is ‘Saheli’ ? What is the duration of ‘Saheli’ ?
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What is Saheli?
Saheli – The non hormonal contraceptive (Weekly oral contraceptive pill)
Central drug Research Institute (CDRI), Lucknow has developed the molecule ‘Centchroman’ which was marketed by HLL under the brand name Saheli. Introduced in 1991, Saheli has the unique distinction of being the world’s first non-steroidal oral contraceptive pill. It is also unique since it is an indigenously developed drug – the first of its kind., this pill has provided contraception to over 1,000,000 women in India.
How does Saheli work?
For pregnancy to happen the following events are essentially needed:
Production of sperm and ovum (female egg)Fusion of sperm and ovum (fertilization)Implantation of fertilized ovum to inner lining of uterus (nidation)
All contraceptives act by interfering with one or more of the above events. Saheli’s contraceptive action is not produced by influencing the Hypothalamo-Pituitiary-Ovarian (HPO) axis. Saheli’s contraceptive action is induced by prevention of implantation through localized action at the uterine environment.
Saheli has weak estrogenic and potent anti-estrogenic action. The contraceptive action of Saheli is caused by asynchrony created in preparing the uterus for implantation. This asyncrony is caused by:
Accelerated tubal transport of embryoAccelerated blastocyst formationDelayed zona sheddingSuppression of uterine decidualisation
Since there is no disturbance of the endocrine system, normal ovulatory cycle is maintained. Side effects commonly associated with hormonal pills are absent with Saheli. The contraceptive effect is readily reversible and subsequent pregnancy is normal. The relative safety and dosage simplicity further ensures excellent user compliance with Saheli.
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Saheli – The non hormonal contraceptive (Weekly oral contraceptive pill)
Central drug Research Institute (CDRI), Lucknow has developed the molecule ‘Centchroman’ which was marketed by HLL under the brand name Saheli. Introduced in 1991, Saheli has the unique distinction of being the world’s first non-steroidal oral contraceptive pill. It is also unique since it is an indigenously developed drug – the first of its kind., this pill has provided contraception to over 1,000,000 women in India.
How does Saheli work?
For pregnancy to happen the following events are essentially needed:
Production of sperm and ovum (female egg)Fusion of sperm and ovum (fertilization)Implantation of fertilized ovum to inner lining of uterus (nidation)
All contraceptives act by interfering with one or more of the above events. Saheli’s contraceptive action is not produced by influencing the Hypothalamo-Pituitiary-Ovarian (HPO) axis. Saheli’s contraceptive action is induced by prevention of implantation through localized action at the uterine environment.
Saheli has weak estrogenic and potent anti-estrogenic action. The contraceptive action of Saheli is caused by asynchrony created in preparing the uterus for implantation. This asyncrony is caused by:
Accelerated tubal transport of embryoAccelerated blastocyst formationDelayed zona sheddingSuppression of uterine decidualisation
Since there is no disturbance of the endocrine system, normal ovulatory cycle is maintained. Side effects commonly associated with hormonal pills are absent with Saheli. The contraceptive effect is readily reversible and subsequent pregnancy is normal. The relative safety and dosage simplicity further ensures excellent user compliance with Saheli.
please click brainlist
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