Question

What is TCA cycle ? explain ?​

Answer 1

Explanation:

the citric acid cycle (CAC) also known as the TCA cycle (tricarboxylic acid cycle) or the krebs cycle us a series of chemical reaction used by all aerobic organisms of a cycle COA derived from carbohydrates fats and proteins into adenosine triphosphate (ATP) and carbon dioxide in addition the cycle provide precursors of certain amino acid as well as the reducing agent NADH that are used in numerous other reaction it's central important to many biochemical pathways suggest that it was one of the earliest established components of cellular metabolism and may have originated abiogenicall.

Answer 2

Answer:

TCA cycle is nothing but Tri Carbolic Acid cycle

also known as Kreb's cycle named after the scientist Hans Krebs (it was first studied by him)

Explanation:

the substrate for this cycle is Acetyl Co-A which is formed by oxidation of pyruvic acid

steps involved:

1. Condensation

acetyl coA along with oxaloacetic acid and water gives citric acid by the action of CITRIC SYNTHETASE enzyme

2. Dehydration

citric acid looses water to give cis aconotic acid by the action of ACONITASE enzyme

3. Hydration

cis aconitic acid reacts with water to give iso citric acid by the action of ACONITASE enzyme

4. Oxidation I

it is done by oxidation of NAD to NADH+H^+ , here isocitric acid is converted to oxalosuccinic acid by the action of enzyme ISOCITRIC DEHYDROGENASE

5. Decarboxylation

oxalosuccinic acid looses CO2 to give ∝-ketoglutaric acid by the action of OXALOSUCCINIC DECARBOXYLASE

6. Oxidation II

it is oxidative decarborylation of ∝-ketoglutaric acid to succinly coA by the action of ∝-KETOGLUTARIC DEHYDROGENASE

7. Cleavage

succinyl coA splits into succinic acid and coA by the action of SUCCNIC THIOKINASE enzyme

8. Oxidation III

succinic acid is converted to fumaric acid by the action of SUCCINIC DEHYDROGENASE enzyme, here FAD is oxidised to FADH2

9. Hydration

fumaric acid along with h2o is converted to malic acid by the action of FUMARASE enzyme

10. Oxidation IV

malic acid is converted to oxaloacetic acid by the action of MALIC DEHYDROGENASE enzyme, here NAD is oxidised to NADH+H^+

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