What is TCA cycle ? explain ?
Answers
Explanation:
the citric acid cycle (CAC) also known as the TCA cycle (tricarboxylic acid cycle) or the krebs cycle us a series of chemical reaction used by all aerobic organisms of a cycle COA derived from carbohydrates fats and proteins into adenosine triphosphate (ATP) and carbon dioxide in addition the cycle provide precursors of certain amino acid as well as the reducing agent NADH that are used in numerous other reaction it's central important to many biochemical pathways suggest that it was one of the earliest established components of cellular metabolism and may have originated abiogenicall.
Answer:
TCA cycle is nothing but Tri Carbolic Acid cycle
also known as Kreb's cycle named after the scientist Hans Krebs (it was first studied by him)
Explanation:
the substrate for this cycle is Acetyl Co-A which is formed by oxidation of pyruvic acid
steps involved:
1. Condensation
acetyl coA along with oxaloacetic acid and water gives citric acid by the action of CITRIC SYNTHETASE enzyme
2. Dehydration
citric acid looses water to give cis aconotic acid by the action of ACONITASE enzyme
3. Hydration
cis aconitic acid reacts with water to give iso citric acid by the action of ACONITASE enzyme
4. Oxidation I
it is done by oxidation of NAD to NADH+H^+ , here isocitric acid is converted to oxalosuccinic acid by the action of enzyme ISOCITRIC DEHYDROGENASE
5. Decarboxylation
oxalosuccinic acid looses CO2 to give ∝-ketoglutaric acid by the action of OXALOSUCCINIC DECARBOXYLASE
6. Oxidation II
it is oxidative decarborylation of ∝-ketoglutaric acid to succinly coA by the action of ∝-KETOGLUTARIC DEHYDROGENASE
7. Cleavage
succinyl coA splits into succinic acid and coA by the action of SUCCNIC THIOKINASE enzyme
8. Oxidation III
succinic acid is converted to fumaric acid by the action of SUCCINIC DEHYDROGENASE enzyme, here FAD is oxidised to FADH2
9. Hydration
fumaric acid along with h2o is converted to malic acid by the action of FUMARASE enzyme
10. Oxidation IV
malic acid is converted to oxaloacetic acid by the action of MALIC DEHYDROGENASE enzyme, here NAD is oxidised to NADH+H^+
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