what is the advantages and disadvantages of knock-out mice on the environment?
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advantages - Against those disadvantages are several important advantages to using knockout mice in behavioral research: (1) disabling a gene is often a very precise and "clean" ablation, (2) the effects of the gene product can be abolished without the side-effects of drugs, and (3) genetic manipulations may be the only way to development in genetics.
disadvantages - Disadvantages. They can be unrepresentative to discover the function of a particular gene. The inactivation of the gene in mice embryos is lethal to around 15% of developing embryos and this restricts the amount of knockout mice that can be observed.
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