Question

What is the cause of formation of carboxy hemoglobin? How is it harmful for 2 us?

Answer 1

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✭ What is the cause of formation of carboxy haemoglobin? How is it harmful for us?



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Carboxyhemoglobin (COHb) is a stable complex of carbon monoxide that forms in red blood cells when carbon monoxide is inhaled.

★ cɑrbon monoxide + hɑemoglobin ➞

cɑrboxy hɑemoglobin

Carboxyhaemoglobin (COHb) is formed when carbon monoxide (CO) binds to the ferrous iron found in haemoglobin. Haemoglobin’s affinity for CO is 218 times greater than that for oxygen (O2), which results in CO displacing O2 during competition for haem binding sites. Low concentrations of CO in inhaled air can cause rapid formation of COHb; 0.1% CO can result in 50% of haemoglobin converting to COHb and notable clinical symptoms will arise within one hour. Levels of 0.2% CO can lead to death within a few hours. Although CO binds to haemoglobin at a slower rate than O2, its greater binding affinity means that it is released 10,000 more slowly from haemoglobin.

Answer 2

Answer :-

Carboxyhemoglobin (COHb), which normally comprises less than 1-2 % of total hemoglobin, is the product of reaction between carbon monoxide and hemoglobin. Carbon monoxide is produced endogenously but is also a common environmental pollutant; both sources contribute to the amount of COHb in blood.

Carboxyhemoglobin is produced by the binding of carbon monoxide (CO) to hemoglobin. CO is generated during incomplete combustion of organic products and has toxic effect because it competes with oxygen for the same binding site in the Fe2+ of Hb. Hemoglobin bound to CO is unable to transport O2.

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