what is the central dogma of life?
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Module 4 : Molecular Cell Biology
Lecture 25 : Central Dogma of Life
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Central Dogma of Life
Introduction: Life of an organism required co-ordinated function of different organs or tissues. Even in the unicellular system, cellular processes are controlled by a series of molecular events, mostly controlled by signal transduction. Signal transduction is a series of phosphorylation events performed by protein kinases. In addition, co-ordination between different organs through messenger molecules, which are also be proteinous in nature. In addition, the phenotypic changes (skin color, feather and pattern) in an organism are required for adaptation and biological demands such as selecting suitable life partner. Most of these examples are associated with the synthesis of suitable protein factor in a time and context dependent manner. The protein is made up of amino acids and every protein has unique amino acid arranged in a specific sequence. The information to synthesize proteins with unique amino acid sequence is provided by the nucleic acid present within the nucleus. In a preset sequence, DNA present in the nucleus give rise to the specific RNA sequence and that in turn guide the cellular machinery to synthesize protein (Figure 25.1). Scientist considered this as the fundamental event to run the life and considered as “central dogma of life”. In another word Francis in his communication to jounrla Nature states “The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information. It states that such information cannot be transferred back from protein to either protein or nucleic acid”.

Figure 25.1: Sequence of Information Flow in Biological System.
The central dogma of life is the basis of life on earth and required to control the biological processes. Following this hierarchical flow of information from DNA to protein allows nucleus to control all biological activitires in a cell. Under normal conditions, the flow of information sequence-to-sequence requires 3 process (Figure 25.2). The three process required for flow of information is as follows:
(1) Sequence dependent synthesis of DNA from pre-exisitng DNA [Replication].
(2) Sequence dependent synthesis of RNA from DNA [Transcription].
(3) Sequence dependent synthesis of DNA from pre-exisitng DNA [Translation].
1
2
3
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if you google it you can get rather than asking
Lecture 25 : Central Dogma of Life
1
2
3
4
Central Dogma of Life
Introduction: Life of an organism required co-ordinated function of different organs or tissues. Even in the unicellular system, cellular processes are controlled by a series of molecular events, mostly controlled by signal transduction. Signal transduction is a series of phosphorylation events performed by protein kinases. In addition, co-ordination between different organs through messenger molecules, which are also be proteinous in nature. In addition, the phenotypic changes (skin color, feather and pattern) in an organism are required for adaptation and biological demands such as selecting suitable life partner. Most of these examples are associated with the synthesis of suitable protein factor in a time and context dependent manner. The protein is made up of amino acids and every protein has unique amino acid arranged in a specific sequence. The information to synthesize proteins with unique amino acid sequence is provided by the nucleic acid present within the nucleus. In a preset sequence, DNA present in the nucleus give rise to the specific RNA sequence and that in turn guide the cellular machinery to synthesize protein (Figure 25.1). Scientist considered this as the fundamental event to run the life and considered as “central dogma of life”. In another word Francis in his communication to jounrla Nature states “The central dogma of molecular biology deals with the detailed residue-by-residue transfer of sequential information. It states that such information cannot be transferred back from protein to either protein or nucleic acid”.

Figure 25.1: Sequence of Information Flow in Biological System.
The central dogma of life is the basis of life on earth and required to control the biological processes. Following this hierarchical flow of information from DNA to protein allows nucleus to control all biological activitires in a cell. Under normal conditions, the flow of information sequence-to-sequence requires 3 process (Figure 25.2). The three process required for flow of information is as follows:
(1) Sequence dependent synthesis of DNA from pre-exisitng DNA [Replication].
(2) Sequence dependent synthesis of RNA from DNA [Transcription].
(3) Sequence dependent synthesis of DNA from pre-exisitng DNA [Translation].
1
2
3
4
if you google it you can get rather than asking
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DNA and RNA
DNA and RNA are the central dogma of life.
DNA makes RNA, and RNA builds protein in our body. Proteins of our body are made by RNA. This process starts from DNA.
DNA makes RNA with the help of Oxygen and RNA starts to make protein. Proteins are very important structure of Human body.
In this process of making RNA, There are 3 important processes and they are as follows:
1) Transcription
2) Translation
3) Replication
DNA stands for => Deoxyribo Nucleic Acid
RNA stands for => Ribo Nucleic Acid.
=> DNA makes RNA and the RNA builds protein in our body.
=> formation of new DNA from old DNA is called as DNA REPLICATION.
=> Central dogma of life was first stated by Francis Crick in 1957
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